Are common reductionistic evidenced based clinical research meaningless, at best?

NB the “?” at the end of the tittle! NB also the word “clinical”!
Also related to the below is While Evidenced Based Medicine is not enough effective in clinical work | Biopsychosocial Medicine and as well as and Evidenced based falsification of data or validation of the individual patient in front of us? | Biopsychosocial Medicine and Challenges for future care: Here focusing only on “who decides – normative evidence vs clinical ideographic evidence” | Biopsychosocial Medicine

First, in many very complex, not well understood diseases/problems/.. just to do a study on just one (independent variable) parameter when knowledge based (real life – biopsychosocial paradigm based, a priori predictions are multifaceted (including assumed synergy interactions between x number of independent variables) makes no sense – using control group including. But there are ways if we use the individual as point of departure*.

NB. I focus mainly on lifestyle related diseases/problems/..
To be able to get an improved “picture” of individual – there within and between variations – we need a totally other kind of focused methodology design., stating at ideographic level and the move upwards (?) to nomothetical level.

My way to address this is … (text coming)

Right now very brief, my “way” based on integrated psychophysiological behavioral medicine is summarized at (in terms of “patients as a reasonable competent educated recourses and coworkers in own rehab”) (HELLA, not just to be considered in Medicine? | Cultural Medicine .. )