BvS 2017-09-23 NB really not ready text! Be careful!

A. Some scientific problem related to real world

The discussion below concerns relations between applied science and real world in general and its support of lifestyle related medicine in particular – in terms of applied science in support of human health and not the reverse – which we do see out of a number of perspective. But here I only emphasis some basics of applied science of medicine and its relevance for individuals, who vary in a varying way between and within individuals and situations (there e.g. blood pressure is measured) over time. This discussion is motivated by the lack of use of some disciplines as integrated neuropsychophysiological behavioral medicine (and biopsychosocial medicine), which systems integration is needed both at a scientific level as well as its applications in health care systems!

Among issues to be elaborated are some common concept as

1. Dependent/independent variable, what is “We regard the respiration behavior of our patients as a key and a tool for a better understanding. It provides a practical clinical measure for the diagnosis and training both on-line and over time. Respiration is both the independent and dependent variable (Ley, 1994) depending on where you are positioned – and so is the patient (Kelly, 1955)” (von Scheele & von Scheele, 1999‘). From a real world complex interaction nested loops², which is discussed below. Only during extremely well controlled experiment in a, not, system integrating multifaceted approach can isolated single factors influence on a single outcome variable! Therefore this conceptualization is not applicable for analyses of living organisms behaviors.
2. Induction and deduction where often abducation (see e.g. https://en.wikipedia.org/wiki/Abductive_reasoning#1867) is not part of the discussion, see e.g. http://www.geocities.ws/sepety/Hume.htm result in a, as above (“1”) discussed, also a kind of distancing from organisms usually complex behaviors which pragmatism (see https://people.ucsc.edu/~ktellez/abduction.pdf and http://www.textlog.de/7664.html) which George Kelly concretized into clinical practice;

3. S-R-loop or Nested loops‘‘, e.g. hypocapnia and its complex system buffering/compensation/adaption consequences (see e.g. https://technet.microsoft.com/sv-se/library/ms191318(v=sql.105).aspx)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670772/ With chronic hypocapnia and the resultant increase in systemic pH, decreases in reabsorption of HCO3− in the proximal tubule and distal tubule H+ secretion result in a fall in plasma HCO3−; these changes can begin within a very few hours (81). With chronic hypercapnia, increased proximal and distal H+ secretion results in increased HCO3− reabsorption and increased production of new HCO3−, resulting in a higher level of plasma HCO3−; most of the cell and molecular mechanisms parallel the response to metabolic acid loads, where these have been studied (82). Increased NH4+ excretion is expected as well with chronic respiratory acidosis (83). With the ubiquitous changes that occur in response to acidosis or acid loads, many investigators have looked for acid sensors; a variety of proteins seem to serve some of this function, but no single sensor can be proposed (25). Se also http://fblt.cz/en/skripta/vii-vylucovaci-soustava-a-acidobazicka-rovnovaha/7-acidobazicka-rovnovaha/ below from https://fmss12uchemd.wordpress.com/2013/05/07/bicarbonate-buffer-systems/

We have discussed this also to some extent in von Schéele, B.H.C. & von Schéele I.A.M.(1999c). The Measurement of Respiratory and Metabolic Parameters of Patients and Controls Be­fore and After Incremental Exercise on Bicycle: Supporting the Effort Syndrome Hypothesis? Applied Psychophysiology and Biofeedback, Vol. 24, No 3. 167-177

Can the above three concerns have a common denominator? I am thinking on difference between a reductionistic and multifaceted systems integrating perspective/paradigm – as well as subject matter for applied sciences. Can we really be concerned with (a) dependent and independent variable, (b) fighting on whether induction and deduction is the right ”way” or (c) S-R-loops when we are concerned with science trying to support humans medical/psychological/psychiatric suffering (or trying to prevent) form diseases and mental problems?

Is such short-coming the reason for preventing a development of systems integrating biopsychosocial medicine? Let be give a simple example; Biofeedback refers usually to … (text will emerge here ..)

More later: A question arises, what is independent and dependent variable in complex systems?

‘  von Schéele, B.H.C. & von Schéele I.A.M.(1999c). The Measurement of Respiratory and Metabolic Parameters of Patients and Controls Be¬fore and After Incremental Exercise on Bicycle: Supporting the Effort Syndrome Hypothesis? Applied Psychophysiology and Biofeedback, Vol. 24, No 3. 167-177

‘‘ The nested loops join, also called nested iteration, uses one join input as the outer input table (shown as the top input in the graphical execution plan) and one as the inner (bottom) input table. The outer loop consumes the outer input table row by row. The inner loop, executed for each outer row, searches for matching rows in the inner input table. In the simplest case, the search scans an entire table or index; this is called a naive nested loops join. If the search exploits an index, it is called an index nested loops join. If the index is built as part of the query plan (and destroyed upon completion of the query), it is called a temporary index nested loops join. All these variants are considered by the query optimizer. A nested loops join is particularly effective if the outer input is small and the inner input is preindexed and large. In many small transactions, such as those affecting only a small set of rows, index nested loops joins are superior to both merge joins and hash joins. In large queries, however, nested loops joins are often not the optimal choice

B – Evolution a head

Evolution´s development = increased adaptation which can be (a) hardware  – more blueprint related, e.g. microorganisms or (b) software related. The latter requires an evolution towards increased flexibility HS cannot manage, which lead to the development of spine towards increased brain development. More and more complex and sophisticated which at primate and homo sapiens levels move from adapt to towards organisms modify the context/environment/…  towards “man as a problem-solver”. Nor yet we see clear signs of SW free itself from HW, which probably will be the next huge step in a few hundred years – given homo sapiens has not finished the prerequisites for it.  A big silence.

As man increases to change its biography more and more (epigenetics, neurogenesis,.. – Kelly, Kendal, Nader,..) new brain gradually take over the dominance of the ole brain (mammalian and reptilian parts). Moving from spatial to temporal dominance which motivate the development of creativity/innovation (both constructive and destructive!). The dominance of internalization, mirror neuron imprinting changes the prerequisites for individuals´ development which more and more miss the history of mankind as well as individual´s biography – the road ahead will be controlled by other forces! The crucial question in the near future will be, as I see it, whether humanistic, democratic forces will be able to cope with and control profits, Alpha male/female power fighting, physical and psychological/psychiatric violence!

Given this – not much sign of so far – evolution can be something great in a dark world – probably, there are somewhere in Universe this has succeeded, which may be to our advantage – which probably will needed – unless …